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Tell your doctor or pharmacist if you are taking any other medicines, including any that you get without a prescription from your pharmacy, supermarket or health food shop. If you have not told your doctor about any of the above, tell them before you start taking this medicine. Tell your doctor if you have any of the following medical conditions: Tell your doctor if you have any allergies to any medicines, foods, preservatives or dyes. If you are not sure whether you should take this medicine, talk to your doctor. If it has expired or is damaged, return it to your pharmacist for disposal. Ask your doctor about the risks and benefits involved.ĭo not use after the expiry date printed on the pack or if the packaging is torn or shows signs of tampering. It is not known whether it is safe to take isosorbide mononitrate whilst you are pregnant or breast-feeding. You must not use isosorbide mononitrate whilst taking sildenafil (Viagra®), vardenafil (Levitra®), tadalafil (Cialis®).ĭo not use this medicine to treat acute angina.ĭo not take isosorbide mononitrate tablets if you are pregnant, plan to become pregnant or are breastfeeding. pericarditis (swelling around the heart).shock, including when caused by low blood pressure or heart failure.swelling of the face, lips, tongue, throat or other parts of the bodyĭo not take this medicine if you are intolerant or allergic to lactose.ĭo not take isosorbide mononitrate if you have or have had any of the following medical conditions:.Some of the symptoms of an allergic reaction may include: any ingredients listed at the end of this leaflet.Before you take this medicine When you must not take itĭo not take this medicine if you have any allergy to: There is not enough information to recommend the use of this medicine in children. This medicine is only available with a doctor's prescription.
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Your doctor may have prescribed it for another reason.
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It is not recommended that isosorbide mononitrate be taken for the treatment of acute attacks.Īsk your doctor if you have any questions about why this medicine has been prescribed for you. It works by relaxing the blood vessels, letting more blood and oxygen reach the heart. Isosorbide mononitrate belongs to a group of medicines called nitrates.
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The pain of angina is usually brought on by exercise or stress. This is caused by too little blood and oxygen getting to the heart. Isosorbide mononitrate sustained-release tablets are used to prevent angina.Īngina is a pain or uncomfortable feeling in the chest, often spreading to the arms or the neck and sometimes to the shoulders and back. If you have any concerns about taking this medicine, ask your doctor or pharmacist Your doctor has weighed the risks of you taking isosorbide mononitrate against the benefits they expect it will have for you. It does not take place of talking to your doctor or pharmacist.Īll medicines have risks and benefits. It does not contain all the information that is known about this medicine. Because asymmetrical dosing creates irregular, sawtooth-like changes in plasma concentrations and a fall below a critical threshold level during the night, tolerance does not develop.This leaflet answers some of the common questions people ask about isosorbide mononitrate. An asymmetrical dosage regimen of isosorbide mononitrate has been shown to provide antianginal efficacy for at least 12 hours. Its pharmacokinetic profile is consistent and highly reproducible and is unchanged in the elderly and in patients with coronary artery disease, renal failure, or liver cirrhosis. Isosorbide mononitrate follows dose-linear kinetics after single and multiple doses. Only 1-2% of an orally administered dose is excreted unchanged in the urine, with the remainder being eliminated as inactive metabolites. The half-life is approximately 5 hours, the volume of distribution is 0.62 liter/kg, and the systemic clearance is 115 mL/min. Pharmacokinetic studies show that isosorbide mononitrate is rapidly absorbed after oral administration, reaches peak concentrations within an hour, undergoes no significant first-pass metabolism, and is virtually 100% bioavailable.